Serious photocontact dermatitis induced by topical ketoprofen depends on the formulation

Serious photocontact dermatitis induced by topical ketoprofen depends on the formulation.

BACKGROUND Topical administration of ketoprofen to treat local subcutaneous pain significantly reduces gastrointestinal and cardiovascular adverse effects associated with oral delivery. However, this benefit must be weighed against the risk of photosensitisation/phototoxicity. OBJECTIVE To substantiate the safety and efficacy of topical ketoprofen delivery from a patch. METHODS Experiments ...

Ketoprofen-induced photoallergic dermatitis

Drug-induced photosensitivity reactions are significant adverse effects. Ketoprofen is one of the most common drugs that can cause skin rash in sun-exposed areas. Non-steroidal anti-inflammatory drugs (NSAIDs), such as ketoprofen, are often used for a variety of symptoms, including pain and fever. An understanding of the presentation and clinical course of ketoprofen-induced photosensitivity is...

Topical dexketoprofen as a cause of photocontact dermatitis.

We reported on the case of a patient who developed a cutaneous eruption in a photoexposed area 1 week after a continous topical treatment with dexketoprofen (Enangel). Photopatch tests were positive for dexketoprofen, ketoprofen and piketoprofen and patch test was positive for piketoprofen. Control photopatch testing with dexketoprofen in 15 healthy volunteers was negative. Dexketoprofen, ketop...

Lymphomatoid photocontact dermatitis to benzydamine hydrochloride.

SERIOUS ARRHYTHMIA INDUCED BY TERFENADINE-ERYTHROMYCIN INTERACTIONS

Since the introduction of our local manufacturing of terfenadine, we have observed and expressed our concern about a small but increasing number of serious ventricular arrhythmias associated with the use of this non sedating antihistamine. In January 1997 a case of torsade de pointes ventricular tachycardia was detected in a previously healthy woman taking terfenadine with erythromycin. El...